POS0191 ANTIMALARIAL DRUGS AND ELECTROCARDIOGRAPHIC ALTERATIONS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

Background During the first months of Sars-CoV-2 pandemic, antimalarial drugs were central axis treatment patients with acute respiratory infection. After that, several studies reported a risk prolongation corrected QT interval (QTc) at electrocardiogram (ECG). Historically, these drugs, have been common denominator in Systemic Lupus Erythematosus (SLE). Objectives To analyze possible relationship between use ant electrocardiographic alterations diagnosed SLE. Methods Cross-sectional study SLE (SLICC 2012). In all them, we performed 12-lead ECG rest. We measured interval: manually and automatically, its correction was made according to Hodge formule (QTc). Results 91 included study. Of total study, 64 current an drug, mean 9.09 (5.73) years treatment, cumulative dosage 813.16 (436.12) gr. on 4.69% had prolonged QTc, compared 3.7% without drugs. Table 1. NO antimalarialn= 27 YES Heart disease 7 (25,93%) 5 (7,81%) Cumulative HCQ (gr ) 316,41 (457,28) 813,16 (436,12) disorders (18,52%) 12 (18,75%) Structural 1 (3,7%) 6 (9,38%) Electrical conduction 2 (7,41%) analyzed QTc interval, cumulated this medication. lineal regression models by evolution, presence or absence known heart disease, women gender, other treatments such as antiarrhythmics beta-blockers. found statistically significant association taking elongated (p= 0,001). Nevertheless, multivariate analysis, did not Figure Conclusion our observe direct intake alteration interval. References N/A Disclosure Interests None declared